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I think just like with other creature, you get a more aggressive one sometimes. I have one huge female that will actually jump on my hand and pick at my skin every time i put my hand in the tank. I've never seen her on the plecos or other fish, but as soon as my hand goes in, she's on it, and trying to eat me alive. lol I actually have to shake my hand to get her off, and let me tell you it doesn't exactly tickle. Not a big pain either, put I could imagine it would be a strong weapon against any other fish in the tank.