I found them very sensitive to acclimatization from the wild and, after that, even after several years, stressed for a long time by re-homing to even the same water parameters, as well.
But other then that I believe it depends on how lucky you are with the particular import batch. I had bought these beautiful fishes may be 5 or so times over several years from the same local importer and, except for the last (current) group, there was always different issues with them - not eating / sickness (very sensitive to ich) / sensitivity to the water params instability, specially pH crash (even more then other plecos).
I didn't have those usual problems with my current group - from the beginning they were healthy, active and not skinny, and I got a good M/F ratio, so they got dedicated 29g which was empty after my L340 breeding project finished. Still - lost several fishes. They are mach more territorial then similarly sized hypancistruses. Tried wet / dry periods simulation on them, different type of foods for may be 18-20 months after which they were rehomed to 65g "pleco community" tank as I needed space for (very successful) L260 project.
This 65g is old and stable, eco complete substrate, lots of caves covered by wood. Similar sized small plecos - L239, L260, L340, L288. Temp 27, 50%wc/3days, 50ppm hardness, pH ~6.5 . Feeding a mix of NLS with 50% of it Algae Max pallet and wafers. Lots of current.
L260 and L340 are spawning periodically in this tank, but till recent I've never seen L239 even occupying a cave. 1st spawn attempt was a "dry run", 2nd attempt was in a week and so far is a total success (after RAMs are in a separate tank).